Micro RNAs as a Diagnostic Marker between Glioma and Primary CNS Lymphoma: A Systematic Review

Differentiating glioma from primary central nervous system lymphoma (PCNSL) can be challenging, and current diagnostic measures such as MRI biopsy are of limited efficacy. Liquid biopsies, which detect circulating biomarkers microRNAs (miRs), may provide valuable insights into for improved discrimination. This review aimed to investigate the role specific miRs in diagnosing differentiating PCNSL. A systematic search was conducted PubMed, Scopus, Web Science, Embase articles on liquid biopsies a method Sixteen dysregulated were identified with significantly different levels PCNSL, including miR-21, most prominent miR higher followed by glioma, glioblastoma (GBM), control groups. The lowest miR-16 miR-205 observed PCNSL groups, whereas miR-15b miR-301 both tumor highest patients. miR-711 (including GBM) downregulated compared group. suggests that using these six unique changing patterns could aid better discrimination between especially GBM,